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Unravelling the Connection Between Inflammation and Concussion

Updated: Aug 4, 2023

Welcome back to The Concussion Discussion, where we delve into the world of head injuries and their impact on brain health. Today, we set our sights on a topic that has garnered significant attention in recent years - the intricate link between inflammation and concussion.

Inflammation is an essential aspect of the body's immune response, serving to protect us against infections and repair damaged tissues. However, when inflammation occurs in the brain due to a concussion, the situation becomes more complex.

Unravelling the link between inflammation and concussion
Inflammation and Concussion

The Inflammatory Response

Studies have shown that the brain undergoes a cascade of inflammatory events following a concussion. The initial impact triggers the release of pro-inflammatory molecules, such as cytokines and chemokines, at the site of injury. These signalling molecules act as alarm bells, summoning immune cells to the affected area to initiate the healing process.

However, when inflammation becomes excessive or prolonged, it can have detrimental effects on brain cells. Activated immune cells may produce harmful substances, contributing to oxidative stress and further damage.

It becomes evident that the inflammatory response is a double-edged sword. On one hand, the initial surge of inflammatory molecules serves as a vital defense mechanism, mobilizing immune cells to the site of injury to begin the repair process. This acute inflammation is essential for clearing away damaged cells and fostering tissue regeneration.

However, on the other hand, if left unchecked, inflammation can become a threat to brain health. The brain's unique environment, enclosed within the protective skull, leaves little room for excess fluid or swelling. Therefore, prolonged inflammation can cause increased pressure within the cranial cavity, potentially leading to secondary brain damage and worsened symptoms.

Moreover, the brain's intricately balanced chemistry can be easily disrupted by inflammation. The influx of pro-inflammatory molecules can disturb the equilibrium of neurotransmitters and disrupt communication between neurons. This imbalance may manifest as cognitive impairments, memory problems, and mood disturbances.

Inflammation and Neurodegenerative Risk

Recent research has also uncovered a potential association between brain inflammation and an increased risk of neurodegenerative diseases later in life. Conditions like chronic traumatic encephalopathy (CTE) and Alzheimer's disease have been linked to repetitive head trauma, which may contribute to chronic inflammation in the brain.

Reducing Inflammation:

Anti-Inflammatory Medications - Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, are commonly used to manage inflammation and alleviate symptoms like headaches. However, the use of these medications should be judicious, as some studies suggest they may interfere with the brain's natural healing processes if used excessively or too early in the recovery phase.

Diet - Omega-3 fatty acids, commonly found in fish oil and certain nuts and seeds, possess anti-inflammatory properties. Consuming a diet rich in antioxidants, such as fruits and vegetables, can also support the brain's healing processes. Click the links for further inflammation on diet and supplements.

Hyperbaric Oxygen Therapy (HBOT) - HBOT involves breathing pure oxygen in a pressurized chamber, which increases oxygen levels in the body and tissues. Some studies suggest that HBOT may reduce inflammation and promote healing after a concussion.

Mindfulness and Stress Reduction - Chronic stress can exacerbate inflammation. Mindfulness techniques, meditation, and relaxation exercises can help manage stress and potentially modulate the inflammatory response.


The connection between inflammation and concussions is a complex puzzle that scientists are tirelessly striving to solve. Whilst the acute inflammatory response is a crucial part of the healing process after a concussion, an excessive or prolonged inflammatory state may lead to more profound issues in the long run. Following a strict diet can help alleviate persistent inflammation - always consult a medical professional before making extreme lifestyle changes.

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